I just had a very close victory against the flagship, for my first victory using the federation cruiser. (Layout A)
After a kind of meh first few sectors, I got a Glaive Beam from an event, which synergized perfectly with my stuff. Pierce shields with burst laser mark 2, wreck em with glaive beam, artillery beam providing fantastic support. The entire time, I was looking for a solid third weapon, like maybe another burst laser mark 2. Unfortunately, I could never find a worthy weapon to fill that slot, so I ended up filling it with just a normal 2 shot burst laser, but it did it's job well enough. I also picked up a defense drone mark 1 at one point.
My run was plagued the entire time with losing crew members in various ways, but I managed to recruit enough new members to fill in the gaps, plus a little.
My goal for the run was to locate the rock homeworlds and possibly do the quest to unlock the rock cruiser, and I did enter the rock homeworlds, but couldn't find the beacon for the start of the quest , which was disappointing. I decided to try my luck at the boss though, since it was a pretty solid run. I figured i'd get dominated by the flagship though.
The first two phases of the fight were a total curbstomp. It hacked my drone system, so my defense drone was useless, but after a few volleys, in each phase, the flagship just melted under my firepower.
The third phase though, is where there was a problem. It's boarding dominance focus proved to be just about too much for me. Between mind controlling my weapons man to kill my zoltan and chunk the weapons system, and the waves of boarders they sent, and the power surges just at the right time to turn the tides, I thought I wouldn't be able to get my weapons running well enough to touch the enemy.
I was wrong. Somehow, I think they stopped mind controlling, possibly due to a lucky artillery beam. Also, all their boarders were sent for the piloting and engines, the far side of the ship from the weapons system. So I repaired the weapons, and with a few volleys, I beat the flagship, surviving with just 4 hp.
TL;DR: average FTL run in all aspects
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