I've been developing a One Punch Mode on the PTR for about a week now.
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Definitely the most popular mode I've made so far. Doesn't work that great with small teams, especially when there's an imbalance, but so does the rest of Overwatch. :V
This current batch of settings allows for all abilities that there is no reason to actively disable like Biotic Field, Supercharger (everything kills in one hit) and so on.
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Capture Speed: 75%
Respawn Time: 60%
Disabled: Genji, McCree, Mei, Roadhog, Symmetra, Torbjorn, Zarya and Zenyatta. (All of them have lethal, ranged alt-fires you can't turn off even if you disable everything for them, eg, Icicle, Fan the Hammer, Orb Volley, etc.)
General Hero Settings:
Ability Cooldowns: 10% (unless otherwise modified)
Damage Delt/Received: both 500%
Health: 25% (10% causes Reinhardt to complain about his shield health. Everything still kills everyone in one shot.)
Movement Speed: 225% (Slight increases should be ~230-240% if you use them)
•Ana: Her perk is Nanoboosting.
Rifle/Grenade/Sleep Dart (Does ranged damage, sorry. Gotta axe it.) all disabled.
300% Ultimate Charge.
Potentially increase speed slightly.
•Bastion: The fastest character.
Disable sentry gun, reconfigure and tank mode. 300% movement speed.
•D.va: Perk is baby D.va giving her a one-time second hit, and defense matrix to counter Orisa.
Disable Boost (OP as hell for this mode) Fusion Cannons and Self-Destruct. (I've had some people suggest adding it since everyone can move so fast it's easy enough to avoid, and it would let her re-Mekka, but I've never tested it.)
•Hanzo: Wall climbing perk. Practically flies after wall-climbing.
Disable Scatter Arrow, Sonic Arrow (would be nice if it didn't do damage) Storm Bow and Dragonstrike.
Potentially increase speed slightly.
•Junkrat: Perk is Mayhem. (Explodes when killed, genuinely dangerous when everyone's melee)
Disable Concussion Mine, Frag launcher, Rip Tire, and probably Steel Trap (or give it a longer cooldown. I've only tested it a little bit with it on, people didn't like it much.)
Potentially increase speed a bit unless you enable traps, in which case decrease it.
•Lucio: Group Speedboost and wallriding.
Disable Sonic Amplifier and Soundwave (OP as hell, don't let people try to convince you to enable it. Just turns the match into all-Lucio mode moreso than usual.) and Crossfade if you don't want him to be able to slow down at all :3c
Set his base speed to 200% (Faster than almost everyone with speed on, fastest when amped up) and 75% cooldown on Amp. (Disable Amp on live servers, the aura is way too big.)
•Mercy: Heros never die. Also gliding I guess.
Disable Cadeuceus Staff (because otherwise she can use her blaster).
300% Ultimate charge rate. Gives her a rez for approximately every 10 kills.
•Orisa: Halt! It doesn't do damage! Therefore it's usable here. But bump up the cooldown to 20% otherwise it's a little much.)
Disable Fusion Driver. (That's it. Everything else is irrelevant to this mode, lol.)
•Pharah: You can fly, you can fly, you can fly ♪
Disable Rocket Launcher and Barrage. Concussive Blast with at least 50% cooldown if at all.
Hover Jets maximum time, 25%, recovery time, 20%, Jump Jets, 50% cooldown. (Because otherwise she can just hover-contest until you get another pharah, hanzo or widowmaker to punch her out of the air.)
•Reaper: Temporary immunity
Disable Hellfire Shotguns and Death Blossom
Wraith Form: 38% (3 seconds between wraithing. No one's really tried him so far in my testing, feel free to tweak.)
250% speed (because he's pretty dang underpowered.)
•Reinhardt: Big area swings, but attacks much slower than everyone else and is a very easy to smack target.
Disable Fire Strike and Earthshatter.
Charge cooldown: I've been doing 50% lately, but it can't be too low otherwise it becomes incredibly overpowered.
Decrease speed to 180%.
•Soldier 76: Marathon Man. (AKA, Sprint.)
Disable Heavy Pulse Rifle, Helix Rockets, and Tactical Visor (it overrides the disable primary fire option, apparently)
Potentially increase his speed a bit.
•Sombra: Stealth mode
Disable Machine Pistol.
Disable Hack & EMP (not that these are necessarily against the spirit of the mode, but it gives her too much advantage.) or you can try alternatively disable stealth/translocator (if you want her to be the hero-disabling-hero.)
Stealth cooldown 20% (so you can't stay hiding nonstop) and Translocator cooldown 25% (so it can't be spammed too much to be fun)
•Tracer: Blink spam!
Disable Pulse Pistols and Pulse Bomb.
Blink Cooldown 30% (about half a second per charge. Spammable but not too frustratingly so.) Recall has a fixed minimum cooldown of 4 seconds presumably so you have a starting point to rewind to.
Potentially slow her down a bit if she's feeling too much of a must-pick.
•Widowmaker: Wallhax and Grappling
Disable Venom Mine and Widow's facebattle.
Ultimate Charge 400%
•Winston: Primal Rage (and optionally Jumppack)
Disable Tesla Gun.
If you only have Primal Rage, 350%. Otherwise, 200%, and JumpPack to whatever you feel is appropriate, I've been doing 60%.
Decrease speed to 180%
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Updated a bit 3/26 since I discovered the primary fire changes made it to live. Tried to remember what all tweaks I did besides lowering the global speed to give Bastion a perk but its hard to remember 'cuz you still can't save them.