Basically Fallout 3 in the Mojave Desert but with more stuff and not so many bugs.
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The story continues some parts of the Fallout and Fallout 2 stories, but is not related in any way to the one in Fallout 3.
Fallout: New Vegas takes place in 2281, three years after the events of Fallout 3 and thirty-nine years after Fallout 2, making this installment set furthest of the series. The New California Republic plays a major part in the story in a three way struggle between the Caesar's Legion slavers and the local New Vegas populace.
The Courier, the player character, is meant to deliver a package to Primm. The Courier is then floored by the Great Khans, and Benny stands in front of the Courier with the Khans cornering the Courier (who is on the ground), holding the platinum chip in his hand. Benny says "Look's like this is going to be your last delivery, kid.", then proceeds to shoot the Courier. The camera zooms out and a Khan can be seen digging a grave for him. He is found by a robot named Victor and is sent to the city of Goodsprings. Mitchell then heals him. He is given some medical tests. The player has the option to recieve training from Sunny Smiles. The player is then pushed back into the open world and the quest Ain't That a Kick in the Head begins. Fallout: New Vegas will have a definitive ending, just like Fallout 3.[2]
http://fallout.wikia.com/wiki/Fallout:_New_Vegas
Its a amazing game!